Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation

BACKGROUND: Mortality from severe acute respiratory distress syndrome exceeds 40% and there is no available pharmacologic treatment. Mechanical ventilation contributes to lung dysfunction and mortality by causing ventilator-induced lung injury. We explored the utility of simvastatin in a mouse model...

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Veröffentlicht in:Respir Res
Hauptverfasser: Manitsopoulos, Nikolaos, Orfanos, Stylianos E, Kotanidou, Anastasia, Nikitopoulou, Ioanna, Siempos, Ilias, Magkou, Christina, Dimopoulou, Ioanna, Zakynthinos, Spyros G, Armaganidis, Apostolos, Maniatis, Nikolaos A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336762/
https://ncbi.nlm.nih.gov/pubmed/25848815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-015-0173-y
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