Combined Mitigation of the Gastrointestinal and Hematopoietic Acute Radiation Syndromes by a Novel LPA(2) Receptor-specific Non-lipid Agonist

Pharmacological mitigation of injuries caused by high-dose ionizing radiation is an unsolved medical problem. A specific nonlipid agonists of the type 2 GPCR for lysophosphatidic acid (LPA(2)) 2-[4-(1,3-Dioxo-1H,3H-benzoisoquinolin-2-yl)butylsulfamoyl]benzoic acid (DBIBB) when administered with a po...

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Publicado en:Chem Biol
Autores principales: Patil, Renukadevi, Szabó, Erzsébet, Fells, James I., Balogh, Andrea, Lim, Keng G., Fujiwara, Yuko, Norman, Derek B., Lee, Sue-Chin, Balazs, Louisa, Thomas, Fridtjof, Patil, Shivaputra, Emmons-Thompson, Karin, Boler, Alyssa, Strobos, Jur, McCool, Shannon W., Yates, C. Ryan, Stabenow, Jennifer, Byrne, Gerrald I., Miller, Duane D., Tigyi, Gábor J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336611/
https://ncbi.nlm.nih.gov/pubmed/25619933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.12.009
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