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Design and Synthesis of Sulfamoyl Benzoic Acid Analogues with Subnanomolar Agonist Activity Specific to the LPA(2) Receptor
[Image: see text] Lysophosphatidic acid (LPA) is a growth factor-like mediator and a ligand for multiple GPCR. The LPA(2) GPCR mediates antiapoptotic and mucosal barrier-protective effects in the gut. We synthesized sulfamoyl benzoic acid (SBA) analogues that are the first specific agonists of LPA(2...
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| Hoofdauteurs: | , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Chemical
Society
2014
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| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4148159/ https://ncbi.nlm.nih.gov/pubmed/25100502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5007116 |
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