Design and Synthesis of Sulfamoyl Benzoic Acid Analogues with Subnanomolar Agonist Activity Specific to the LPA(2) Receptor

[Image: see text] Lysophosphatidic acid (LPA) is a growth factor-like mediator and a ligand for multiple GPCR. The LPA(2) GPCR mediates antiapoptotic and mucosal barrier-protective effects in the gut. We synthesized sulfamoyl benzoic acid (SBA) analogues that are the first specific agonists of LPA(2...

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Bibliografiske detaljer
Main Authors: Patil, Renukadevi, Fells, James I., Szabó, Erzsébet, Lim, Keng G., Norman, Derek D., Balogh, Andrea, Patil, Shivaputra, Strobos, Jur, Miller, Duane D., Tigyi, Gábor J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148159/
https://ncbi.nlm.nih.gov/pubmed/25100502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5007116
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