Bioengineering and Semisynthesis of an Optimized Cyclophilin Inhibitor for Treatment of Chronic Viral Infection

Inhibition of host-encoded targets, such as the cyclophilins, provides an opportunity to generate potent high barrier to resistance antivirals for the treatment of a broad range of viral diseases. However, many host-targeted agents are natural products, which can be difficult to optimize using synth...

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Publicat a:Chem Biol
Autors principals: Hansson, Magnus Joakim, Moss, Steven James, Bobardt, Michael, Chatterji, Udayan, Coates, Nigel, Garcia-Rivera, Jose A., Elmér, Eskil, Kendrew, Steve, Leyssen, Pieter, Neyts, Johan, Nur-E-Alam, Mohammad, Warneck, Tony, Wilkinson, Barrie, Gallay, Philippe, Gregory, Matthew Alan
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Ltd. 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336584/
https://ncbi.nlm.nih.gov/pubmed/25619934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.10.023
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