Preclinical Characterization of Naturally Occurring Polyketide Cyclophilin Inhibitors from the Sanglifehrin Family

Cyclophilin inhibitors currently in clinical trials for hepatitis C virus (HCV) are all analogues of cyclosporine (CsA). Sanglifehrins are a group of naturally occurring cyclophilin binding polyketides that are structurally distinct from the cyclosporines and are produced by a microorganism amenable...

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Detalhes bibliográficos
Main Authors: Gregory, Matthew A., Bobardt, Michael, Obeid, Susan, Chatterji, Udayan, Coates, Nigel J., Foster, Teresa, Gallay, Philippe, Leyssen, Pieter, Moss, Steven J., Neyts, Johan, Nur-e-Alam, Mohammad, Paeshuyse, Jan, Piraee, Mahmood, Suthar, Dipen, Warneck, Tony, Zhang, Ming-Qiang, Wilkinson, Barrie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088210/
https://ncbi.nlm.nih.gov/pubmed/21383094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01627-10
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