Inhibition of UDP/P2Y(6) purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo

Microglia activated through Toll-like receptor (TLR)-2 or -4 can cause neuronal death by phagocytosing otherwise-viable neurons—a form of cell death called “phagoptosis.” UDP release from neurons has been shown to provoke microglial phagocytosis of neurons via microglial P2Y(6) receptors, but whethe...

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Publicado en:Glia
Autores principales: Neher, Jonas J, Neniskyte, Urte, Hornik, Tamara, Brown, Guy C
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336556/
https://ncbi.nlm.nih.gov/pubmed/24838858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22693
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