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Inhibition of UDP/P2Y(6) purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo
Microglia activated through Toll-like receptor (TLR)-2 or -4 can cause neuronal death by phagocytosing otherwise-viable neurons—a form of cell death called “phagoptosis.” UDP release from neurons has been shown to provoke microglial phagocytosis of neurons via microglial P2Y(6) receptors, but whethe...
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| Publicado en: | Glia |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4336556/ https://ncbi.nlm.nih.gov/pubmed/24838858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22693 |
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