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Structure-Function Relationships in Lactate Dehydrogenase

The binding of coenzyme and substrate are considered in relation to the known primary and tertiary structure of lactate dehydrogenase (EC 1.1.1.27). The adenine binds in a hydrophobic crevice, and the two coenzyme phosphates are oriented by interactions with the protein. The positively charged guani...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Adams, Margaret J., Buehner, Manfred, Chandrasekhar, K., Ford, Geoffrey C., Hackert, Marvin L., Liljas, Anders, Rossmann, Michael G., Smiley, Ira E., Allison, William S., Everse, Johannes, Kaplan, Nathan O., Taylor, Susan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1973
Soggetti:
Biological Sciences: Biochemistry
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433644/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4146647/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.7.1968
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