A New Nonpolar N-Hydroxy Imidazoline Lead Compound with Improved Activity in a Murine Model of Late-Stage Trypanosoma brucei brucei Infection Is Not Cross-Resistant with Diamidines

Treatment of late-stage sleeping sickness requires drugs that can cross the blood-brain barrier (BBB) to reach the parasites located in the brain. We report here the synthesis and evaluation of four new N-hydroxy and 12 new N-alkoxy derivatives of bisimidazoline leads as potential agents for the tre...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ríos Martínez, Carlos H., Miller, Florence, Ganeshamoorthy, Kayathiri, Glacial, Fabienne, Kaiser, Marcel, de Koning, Harry P., Eze, Anthonius A., Lagartera, Laura, Herraiz, Tomás, Dardonville, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335899/
https://ncbi.nlm.nih.gov/pubmed/25421467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03958-14
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