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In Vivo Pharmacokinetics and Pharmacodynamics of the Lantibiotic NAI-107 in a Neutropenic Murine Thigh Infection Model

NAI-107 is a novel lantibiotic compound with potent in vitro activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The purpose of this study was to examine the activity of NAI-107 against S. aureus strains, including MRSA, in the neutropenic murine th...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Lepak, Alexander J., Marchillo, Karen, Craig, William A., Andes, David R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335879/
https://ncbi.nlm.nih.gov/pubmed/25512404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04444-14
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