In Vivo Pharmacokinetics and Pharmacodynamics of ZTI-01 (Fosfomycin for Injection) in the Neutropenic Murine Thigh Infection Model against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa

Fosfomycin is a broad-spectrum agent with activity against Gram-positive and Gram-negative bacteria, including drug-resistant strains, such as extended-spectrum-beta-lactamase (ESBL)-producing and carbapenem-resistant (CR) Gram-negative rods. In the present study, the pharmacokinetic/pharmacodynamic...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Lepak, Alexander J., Zhao, Miao, VanScoy, Brian, Taylor, Daniel S., Ellis-Grosse, Evelyn, Ambrose, Paul G., Andes, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444146/
https://ncbi.nlm.nih.gov/pubmed/28396549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00476-17
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