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A Cell-Based Strategy To Assess Intrinsic Inhibition Efficiencies of HIV-1 Reverse Transcriptase Inhibitors

During HIV-1 reverse transcription, there are increasing opportunities for nucleos(t)ide (NRTI) or nonnucleoside (NNRTI) reverse transcriptase (RT) inhibitors to stop elongation of the nascent viral DNA (vDNA). In addition, RT inhibitors appear to influence the kinetics of vDNA synthesis differently...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Abram, Michael E., Tsiang, Manuel, White, Kirsten L., Callebaut, Christian, Miller, Michael D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335843/
https://ncbi.nlm.nih.gov/pubmed/25403670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04163-14
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