Drug Susceptibility and Viral Fitness of HIV-1 with Integrase Strand Transfer Inhibitor Resistance Substitution Q148R or N155H in Combination with Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Resistance Substitutions

In clinical trials of coformulated elvitegravir (EVG), cobicistat (COBI), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF), emergent drug resistance predominantly involved the FTC resistance substitution M184V/I in reverse transcriptase (RT), with or without the tenofovir (TFV) resistanc...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Andreatta, Kristen N., Miller, Michael D., White, Kirsten L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750659/
https://ncbi.nlm.nih.gov/pubmed/26574015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02096-15
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