Microbiome Changes in Healthy Volunteers Treated with GSK1322322, a Novel Antibiotic Targeting Bacterial Peptide Deformylase

GSK1322322 is a novel antibacterial agent under development, and it has known antibacterial activities against multidrug-resistant respiratory and skin pathogens through its inhibition of the bacterial peptide deformylase. Here, we used next-generation sequencing (NGS) of the bacterial 16S rRNA gene...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Arat, Seda, Spivak, Aaron, Van Horn, Stephanie, Thomas, Elizabeth, Traini, Christopher, Sathe, Ganesh, Livi, George P., Ingraham, Karen, Jones, Lori, Aubart, Kelly, Holmes, David J., Naderer, Odin, Brown, James R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2015
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335841/
https://ncbi.nlm.nih.gov/pubmed/25487798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04506-14
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