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Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development
[Image: see text] Antibody–drug conjugates (ADCs) combine the specificity of antibodies with the potency of small molecules to create targeted drugs. Despite the simplicity of this concept, generation of clinically successful ADCs has been very difficult. Over the past several decades, scientists ha...
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| Veröffentlicht in: | Bioconjug Chem |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4335810/ https://ncbi.nlm.nih.gov/pubmed/25494884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc5004982 |
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