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Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

[Image: see text] Antibody–drug conjugates (ADCs) combine the specificity of antibodies with the potency of small molecules to create targeted drugs. Despite the simplicity of this concept, generation of clinically successful ADCs has been very difficult. Over the past several decades, scientists ha...

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Bibliografski detalji
Izdano u:Bioconjug Chem
Glavni autori: Agarwal, Paresh, Bertozzi, Carolyn R.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335810/
https://ncbi.nlm.nih.gov/pubmed/25494884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc5004982
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