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Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats

PURPOSE: We investigated the contribution of cytochrome P450 (CYP) 1B1 to hypertension and its pathogenesis by examining the effect of its selective inhibitor, 2,4,3′,5′-tetramethoxystilbene (TMS), in spontaneously hypertensive rats (SHR). METHODS: Blood pressure (BP) was measured bi-weekly. Startin...

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Vydáno v:Cardiovasc Drugs Ther
Hlavní autoři: Jennings, Brett L., Montanez, David E., May, Michael E., Estes, Anne M., Fang, Xiao R., Yaghini, Fariborz A., Malik, Kafait U., Kanu, Alie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335675/
https://ncbi.nlm.nih.gov/pubmed/24477449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10557-014-6510-4
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