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CYTOCHROME P450 1B1 GENE DISRUPTION MINIMIZES DOCA-SALT-INDUCED HYPERTENSION AND ASSOCIATED CARDIAC DYSFUNCTION AND RENAL DAMAGE IN MICE

Previously, we showed that the cytochrome P450 1B1 inhibitor, 2,3´,4,5´-tetramethoxystilbene, reversed DOCA-salt induced hypertension and minimized endothelial and renal dysfunction in the rat. This study was conducted to test the hypothesis that cytochrome P450 1B1 contributes to cardiac dysfunctio...

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Detalhes bibliográficos
Main Authors: Jennings, Brett L., Estes, Anne M., Anderson, Larry J., Fang, Xiao R., Yaghini, Fariborz A., Fan, Zheng, Gonzalez, Frank J., Campbell, William B., Malik, Kafait U.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499668/
https://ncbi.nlm.nih.gov/pubmed/23108654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.202606
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