Cas9 function and host genome sampling in Type II-A CRISPR–Cas adaptation

To acquire the ability to recognize and destroy virus and plasmid invaders, prokaryotic CRISPR–Cas systems capture fragments of DNA within the host CRISPR locus. Our results indicate that the process of adaptation by a Type II-A CRISPR–Cas system in Streptococcus thermophilus requires Cas1, Cas2, an...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Wei, Yunzhou, Terns, Rebecca M., Terns, Michael P.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2015
Subjects:
Research Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335292/
https://ncbi.nlm.nih.gov/pubmed/25691466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.257550.114
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