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Adapting CRISPR/Cas9 System for Targeting Mitochondrial Genome
Gene editing of the mitochondrial genome using the CRISPR-Cas9 system is highly challenging mainly due to sub-efficient delivery of guide RNA and Cas9 enzyme complexes into the mitochondria. In this study, we were able to perform gene editing in the mitochondrial DNA by appending an NADH-ubiquinone...
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| Pubblicato in: | Front Genet |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8055930/ https://ncbi.nlm.nih.gov/pubmed/33889176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2021.627050 |
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