Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer

Along with breast and endometrial cancers, thyroid cancer is a major component cancer in Cowden syndrome (CS). Germline variants in SDHB/C/D (SDHx) genes account for subsets of CS/CS-like cases, conferring a higher risk of breast and thyroid cancers over those with only germline PTEN mutations. To i...

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Veröffentlicht in:Endocr Relat Cancer
Hauptverfasser: Ni, Ying, Seballos, Spencer, Ganapathi, Shireen, Gurin, Danielle, Fletcher, Benjamin, Ngeow, Joanne, Nagy, Rebecca, Kloos, Richard T, Ringel, Matthew D, LaFramboise, Thomas, Eng, Charis
Format: Artigo
Sprache:Inglês
Veröffentlicht: Bioscientifica Ltd 2015
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335266/
https://ncbi.nlm.nih.gov/pubmed/25694510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-14-0537
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