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Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish

The genetic underpinnings of heart rate regulation are only poorly understood. In search for genetic regulators of cardiac pacemaker activity, we isolated in a large-scale mutagenesis screen the embryonic lethal, recessive zebrafish mutant schneckentempo (ste). Homozygous ste mutants exhibit a sever...

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Pubblicato in:Basic Res Cardiol
Autori principali: Keßler, Mirjam, Berger, Ina M., Just, Steffen, Rottbauer, Wolfgang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335124/
https://ncbi.nlm.nih.gov/pubmed/25697682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-015-0468-7
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