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Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish

The genetic underpinnings of heart rate regulation are only poorly understood. In search for genetic regulators of cardiac pacemaker activity, we isolated in a large-scale mutagenesis screen the embryonic lethal, recessive zebrafish mutant schneckentempo (ste). Homozygous ste mutants exhibit a sever...

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Detalhes bibliográficos
Publicado no:Basic Res Cardiol
Main Authors: Keßler, Mirjam, Berger, Ina M., Just, Steffen, Rottbauer, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335124/
https://ncbi.nlm.nih.gov/pubmed/25697682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-015-0468-7
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