MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome

Children with Down syndrome (DS) are at increased risk for acute myeloid leukemias (ML-DS) characterized by mixed megakaryocytic and erythroid phenotype and by acquired mutations in the GATA1 gene resulting in a short GATA1s isoform. The chromosome 21 microRNA (miR)-125b cluster has been previously...

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Udgivet i:Blood
Main Authors: Shaham, Lital, Vendramini, Elena, Ge, Yubin, Goren, Yaron, Birger, Yehudit, Tijssen, Marloes R., McNulty, Maureen, Geron, Ifat, Schwartzman, Omer, Goldberg, Liat, Chou, Stella T., Pitman, Holly, Weiss, Mitchell J., Michaeli, Shulamit, Sredni, Benjamin, Göttgens, Berthold, Crispino, John D., Taub, Jeffrey W., Izraeli, Shai
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Myeloid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335082/
https://ncbi.nlm.nih.gov/pubmed/25533034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-581892
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