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Acetylation of Sickle Cell Hemoglobin by Aspirin

Incubation of HbS (or HbA) with aspirin leads to incorporation of acetyl groups into the protein. Incorporation was followed by the use of aspirin labeled with (14)C in the acetyl group. The acetylated hemoglobins show an increase in oxygen affinity compared to the parent proteins. If acetylation al...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Klotz, Irving M., Tam, Joseph W. O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1973
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433486/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4514302/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.5.1313
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