Chemical Modifications That Inhibit Gelation of Sickle Hemoglobin

Substitution of the N-terminal amino groups with pyridoxal compounds inhibits gelation and increases the solubility of deoxy sickle hemoglobin (Hb S). Pyridoxylation of the α chains has considerably more effect than that of the β chains. The increase in minimum gelling concentration of Hb S that res...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Benesch, Reinhold, Benesch, Ruth E., Yung, Suzanna
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1974
Предметы:	Biological Sciences: Biochemistry
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC388258/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4524653/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.71.4.1504
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