Variable Transcriptional Regulation of the Human Aldosterone Synthase Gene Causes Salt-Dependent High Blood Pressure in Transgenic Mice

BACKGROUND: Aldosterone, synthesized in the adrenal cortex by the enzyme CYP11B2, induces positive sodium balance and predisposes to hypertension. Various investigators, using genomic DNA analyses, have linked −344T polymorphism in the hCYP11B2 gene to human hypertension. Human CYP11B2 gene promoter...

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Detalhes bibliográficos
Publicado no:Circ Cardiovasc Genet
Main Authors: Mopidevi, Brahmaraju, Kaw, Meenakshi K., Puri, Nitin, Ponnala, Madhusudan, Jain, Sudhir, Rana, Anita, Keetha, Narsimha R., Khuder, Sadik A., Fiering, Steven N., Kumar, Ashok
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334713/
https://ncbi.nlm.nih.gov/pubmed/25504670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.114.000694
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