Molecular Umbrella Conjugate for the Ocular Delivery of siRNA

[Image: see text] The synthesis, computer modeling, and biological activity of an octawalled molecular umbrella short interfacing RNA (siRNA) conjugate is described. This molecular umbrella–siRNA conjugate exhibited mRNA knockdown activity in vitro in the absence of a transfection reagent. Evaluatio...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Bioconjug Chem
Päätekijät: Janout, Vaclav, Cline, Lauren L., Feuston, Bradley P., Klein, Lee, O’Brien, Ann, Tucker, Tom, Yuan, Yu, O’Neill-Davis, Lynn A., Peiffer, Robert L., Nerurkar, Sandhya S., Jadhav, Vasant, Tellers, David M., Regen, Steven L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2014
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334295/
https://ncbi.nlm.nih.gov/pubmed/24433067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc400506m
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