Molecular Umbrella Conjugate for the Ocular Delivery of siRNA

[Image: see text] The synthesis, computer modeling, and biological activity of an octawalled molecular umbrella short interfacing RNA (siRNA) conjugate is described. This molecular umbrella–siRNA conjugate exhibited mRNA knockdown activity in vitro in the absence of a transfection reagent. Evaluatio...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Janout, Vaclav, Cline, Lauren L., Feuston, Bradley P., Klein, Lee, O’Brien, Ann, Tucker, Tom, Yuan, Yu, O’Neill-Davis, Lynn A., Peiffer, Robert L., Nerurkar, Sandhya S., Jadhav, Vasant, Tellers, David M., Regen, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334295/
https://ncbi.nlm.nih.gov/pubmed/24433067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc400506m
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