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Computer-Guided Design, Synthesis, and Protein Kinase C Affinity of a New Salicylate-Based Class of Bryostatin Analogs
[Image: see text] Bryostatin 1 is in clinical trials for the treatment of cancer and Alzheimer’s disease and is a candidate for a first-in-class approach to HIV/AIDS eradication. It is neither readily available nor optimally suited for clinical use. Using a function oriented synthesis strategy, a ne...
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| Veröffentlicht in: | Org Lett |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2014
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4334246/ https://ncbi.nlm.nih.gov/pubmed/25238583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol502491f |
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