BRCA1 haplotype and clinical benefit of trabectedin in soft-tissue sarcoma patients

BACKGROUND: This study aimed to determine whether the BRCA1 haplotype was associated with trabectedin efficacy in soft-tissue sarcoma (STS) patients. METHODS: We analysed BRCA1 single-nucleotide polymorphisms (SNPs) in tumour specimens from 135 advanced STS patients enrolled in published phase 2 tri...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Cancer
Prif Awduron: Laroche-Clary, A, Chaire, V, Le Morvan, V, Neuville, A, Bertucci, F, Salas, S, Sanfilippo, R, Pourquier, P, Italiano, A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Translational Therapeutics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333490/
https://ncbi.nlm.nih.gov/pubmed/25602962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2014.624
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