AP2 controls clathrin polymerization with a membrane-activated switch

Clathrin-mediated endocytosis (CME) is vital for the internalization of most cell-surface proteins. In CME, plasma membrane-binding clathrin adaptors recruit and polymerize clathrin to form clathrin-coated ‘pits’ into which cargo is sorted. AP2 is the most abundant adaptor, and is pivotal to CME. By...

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Bibliografiska uppgifter
I publikationen:Science
Huvudupphovsmän: Kelly, Bernard T., Graham, Stephen C., Liska, Nicole, Dannhauser, Philip N., Höning, Stefan, Ungewickell, Ernst J., Owen, David J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333214/
https://ncbi.nlm.nih.gov/pubmed/25061211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254836
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