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AP2 controls clathrin polymerization with a membrane-activated switch
Clathrin-mediated endocytosis (CME) is vital for the internalization of most cell-surface proteins. In CME, plasma membrane-binding clathrin adaptors recruit and polymerize clathrin to form clathrin-coated ‘pits’ into which cargo is sorted. AP2 is the most abundant adaptor, and is pivotal to CME. By...
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| Veröffentlicht in: | Science |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4333214/ https://ncbi.nlm.nih.gov/pubmed/25061211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1254836 |
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