Single-Stranded γPNAs for In Vivo Site-Specific Genome Editing via Watson-Crick Recognition

Triplex-forming peptide nucleic acids (PNAs) facilitate gene editing by stimulating recombination of donor DNAs within genomic DNA via site-specific formation of altered helical structures that further stimulate DNA repair. However, PNAs designed for triplex formation are sequence restricted to homo...

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Pubblicato in:Curr Gene Ther
Autori principali: Bahal, Raman, Quijano, Elias, McNeer, Nicole Ali, Liu, Yanfeng, Bhunia, Dinesh C., López-Giráldez, Francesco, Fields, Rachel J., Saltzman, W. Mark, Ly, Danith H., Glazer, Peter M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333085/
https://ncbi.nlm.nih.gov/pubmed/25174576
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