β-Catenin Signaling Drives Differentiation and Proinflammatory Function of IRF8-Dependent Dendritic Cells

β-catenin signaling has recently been tied to the emergence of tolerogenic dendritic cells (DC). Here we demonstrate a novel role for β-catenin in directing DC subset development through IRF8 activation. We found that splenic DC precursors express β-catenin, and DC from mice with CD11c-specific cons...

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Publicado no:J Immunol
Main Authors: Cohen, Sara B., Smith, Norah L., McDougal, Courtney, Pepper, Marion, Shah, Suhagi, Yap, George S., Acha-Orbea, Hans, Jiang, Aimin, Clausen, Björn E., Rudd, Brian D., Denkers, Eric Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333072/
https://ncbi.nlm.nih.gov/pubmed/25416805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402453
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