β-Catenin in dendritic cells exerts opposite functions in cross-priming and maintenance of CD8(+) T cells through regulation of IL-10

Recent studies have demonstrated that β-catenin in DCs serves as a key mediator in promoting both CD4(+) and CD8(+) T-cell tolerance, although how β-catenin exerts its functions remains incompletely understood. Here we report that activation of β-catenin in DCs inhibits cross-priming of CD8(+) T cel...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Fu, Chunmei, Liang, Xinjun, Cui, Weiguo, Ober-Blöbaum, Julia L., Vazzana, Joseph, Shrikant, Protul A., Lee, Kelvin P., Clausen, Björn E., Mellman, Ira, Jiang, Aimin
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2015
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352820/
https://ncbi.nlm.nih.gov/pubmed/25730849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414167112
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