Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells

We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 an...

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Publicat a:Pigment Cell Melanoma Res
Autors principals: Webster, Marie R., Xu, Mai, Kinzler, Kathryn A., Kaur, Amanpreet, Appleton, Jessica, O’Connell, Michael P., Marchbank, Katie, Valiga, Alexander, Dang, Vanessa M., Perego, Michela, Zhang, Gao, Slipicevic, Ana, Keeney, Frederick, Lehrmann, Elin, Wood, William, Becker, Kevin G., Kossenkov, Andrew V., Frederick, Dennie T., Flaherty, Keith T., Xu, Xiaowei, Herlyn, Meenhard, Murphy, Maureen E., Weeraratna, Ashani T.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333017/
https://ncbi.nlm.nih.gov/pubmed/25407936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12330
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