Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells

We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 an...

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Publicado no:Pigment Cell Melanoma Res
Main Authors: Webster, Marie R., Xu, Mai, Kinzler, Kathryn A., Kaur, Amanpreet, Appleton, Jessica, O’Connell, Michael P., Marchbank, Katie, Valiga, Alexander, Dang, Vanessa M., Perego, Michela, Zhang, Gao, Slipicevic, Ana, Keeney, Frederick, Lehrmann, Elin, Wood, William, Becker, Kevin G., Kossenkov, Andrew V., Frederick, Dennie T., Flaherty, Keith T., Xu, Xiaowei, Herlyn, Meenhard, Murphy, Maureen E., Weeraratna, Ashani T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333017/
https://ncbi.nlm.nih.gov/pubmed/25407936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12330
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