Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells

We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 an...

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Bibliografiska uppgifter
I publikationen:Pigment Cell Melanoma Res
Huvudupphovsmän: Webster, Marie R., Xu, Mai, Kinzler, Kathryn A., Kaur, Amanpreet, Appleton, Jessica, O’Connell, Michael P., Marchbank, Katie, Valiga, Alexander, Dang, Vanessa M., Perego, Michela, Zhang, Gao, Slipicevic, Ana, Keeney, Frederick, Lehrmann, Elin, Wood, William, Becker, Kevin G., Kossenkov, Andrew V., Frederick, Dennie T., Flaherty, Keith T., Xu, Xiaowei, Herlyn, Meenhard, Murphy, Maureen E., Weeraratna, Ashani T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333017/
https://ncbi.nlm.nih.gov/pubmed/25407936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12330
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