Influence of Leaving-Group Electronic Effect on α-Chymotrypsin: Catalytic Constants of Specific Substrates

Rate constants and binding constants for the α-chymotrypsin-catalyzed hydrolysis of N-acetyltyrosine, tryptophan, and phenylalanine anilides are presented. Both k(cat) and K(m) are independent of electronic effects in the substrate over a range of 9.8 orders of magnitude (as measured by pK of the le...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Philipp, Manfred, Pollack, Ralph M., Bender, Myron L.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1973
Schlagworte:	Biological Sciences: Biochemistry
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC433295/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/16592059/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.70.2.517
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!