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In vivo role of checkpoint kinase 2 in signaling telomere dysfunction
Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis. Successive generation...
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| Publicado no: | Aging Cell |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4331747/ https://ncbi.nlm.nih.gov/pubmed/24920220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12237 |
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