In vivo role of checkpoint kinase 2 in signaling telomere dysfunction

Checkpoint kinase 2 (CHK2) is a downstream effector of the DNA damage response (DDR). Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis. Successive generation...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: García-Beccaria, María, Martínez, Paula, Flores, Juana M, Blasco, Maria A
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331747/
https://ncbi.nlm.nih.gov/pubmed/24920220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12237
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