A novel adenoviral vector carrying an all-in-one Tet-On system with an autoregulatory loop for tight, inducible transgene expression

BACKGROUND: One of the most commonly used vectors for gene therapy is the adenoviral vector; its ability to tightly regulate transgene expression is critical for optimizing therapeutic outcomes. The tetracycline-regulated system (especially the Tet-On system) for gene expression is one of the most v...

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Bibliographic Details
Published in:BMC Biotechnol
Main Authors: Chen, Hao, Wang, Dongyang, Xia, Ruiting, Mao, Qinwen, Xia, Haibin
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331377/
https://ncbi.nlm.nih.gov/pubmed/25888000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-015-0121-4
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