An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

Adenoviral (Ad)-mediated in vivo gene transfer and expression are limited in part by cellular immune responses to viral-encoded proteins and/or transgene immunogenicity. In an attempt to diminish the former responses, we have previously developed and described helper-dependent (HD) Ad vectors in whi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Morsy, Manal A., Gu, MingCheng, Motzel, Sherri, Zhao, Jing, Lin, Jing, Su, Qin, Allen, Henry, Franlin, Laura, Parks, Robin J., Graham, Frank L., Kochanek, Stefan, Bett, Andrew J., Caskey, C. Thomas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20895/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9653106/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.14.7866
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