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An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

Adenoviral (Ad)-mediated in vivo gene transfer and expression are limited in part by cellular immune responses to viral-encoded proteins and/or transgene immunogenicity. In an attempt to diminish the former responses, we have previously developed and described helper-dependent (HD) Ad vectors in whi...

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Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Morsy, Manal A., Gu, MingCheng, Motzel, Sherri, Zhao, Jing, Lin, Jing, Su, Qin, Allen, Henry, Franlin, Laura, Parks, Robin J., Graham, Frank L., Kochanek, Stefan, Bett, Andrew J., Caskey, C. Thomas
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 1998
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20895/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9653106/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.14.7866
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