Convection-enhanced delivery of macromolecules in the brain.

For many compounds (neurotrophic factors, antibodies, growth factors, genetic vectors, enzymes) slow diffusion in the brain severely limits drug distribution and effect after direct drug administration into brain parenchyma. We investigated convection as a means to enhance the distribution of the la...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bobo, R H, Laske, D W, Akbasak, A, Morrison, P F, Dedrick, R L, Oldfield, E H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43312/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8134351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.6.2076
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