Convection-enhanced delivery of macromolecules in the brain.

For many compounds (neurotrophic factors, antibodies, growth factors, genetic vectors, enzymes) slow diffusion in the brain severely limits drug distribution and effect after direct drug administration into brain parenchyma. We investigated convection as a means to enhance the distribution of the la...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Bobo, R H, Laske, D W, Akbasak, A, Morrison, P F, Dedrick, R L, Oldfield, E H
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43312/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8134351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.6.2076
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