Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis.

High-affinity folate receptors (FRs) are expressed at elevated levels on many human tumors. Bispecific antibodies that bind the FR and the T-cell receptor (TCR) mediate lysis of these tumor cells by cytotoxic T lymphocytes. In this report, conjugates that consist of folate covalently linked to anti-...

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Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Kranz, D M, Patrick, T A, Brigle, K E, Spinella, M J, Roy, E J
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1995
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40923/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7568072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.20.9057
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