Pioglitazone restores phagocyte mitochondrial oxidants and bactericidal capacity in Chronic Granulomatous Disease

BACKGROUND: Deficient production of reactive oxygen species (ROS) by the phagocyte NADPH oxidase in Chronic Granulomatous Disease (CGD) results in susceptibility to certain pathogens secondary to impaired oxidative killing and mobilization of other phagocyte defenses. PPARγ agonists including piogli...

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Bibliografiska uppgifter
I publikationen:J Allergy Clin Immunol
Huvudupphovsmän: Fernandez-Boyanapalli, Ruby F., Frasch, S. Courtney, Thomas, Stacey M., Malcolm, Kenneth C., Nicks, Michael, Harbeck, Ronald J., Jakubzick, Claudia V., Nemenoff, Raphael, Henson, Peter M., Holland, Steven M., Bratton, Donna L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331116/
https://ncbi.nlm.nih.gov/pubmed/25498313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.10.034
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